Polynucleotides: The new kid on the block

In the world of non-surgical aesthetic treatments, innovation is constant. One such groundbreaking advancement is the development of polynucleotides (PNs). PNs have rapidly gained popularity in recent years due to their remarkable ability to revitalise the skin, promote collagen production, and enhance overall skin quality. Here we explore their benefits, and why they have become a go-to treatment for individuals seeking non-invasive skin rejuvenation.

What are Polynucleotides?

Polynucleotides, also known as PNs or PDRN (polydeoxyribonucleotide), are biologically active molecules derived from salmon DNA. These long-chain nucleotides are naturally present in our bodies and play a vital role in cell regeneration and wound healing processes. In aesthetic medicine, synthetic PNs are used to promote skin rejuvenation, enhance collagen synthesis, and improve the overall texture and appearance of the skin.

Benefits of Polynucleotides:

  1. Skin Rejuvenation: PNs have been shown to activate fibroblasts, the primary cells responsible for producing collagen. Collagen serves as a key protein providing structural support to the skin, and increased collagen production helps improve skin elasticity, firmness, and overall texture, reducing the appearance of wrinkles and fine lines. By promoting cell regeneration, PNs can improve skin texture, reduce the appearance of fine lines and wrinkles, and rejuvenate dull or damaged skin.

  2. Wound Healing and Tissue Repair: PNs contain nucleotides that play a crucial role in DNA synthesis and repair, and stimulate cellular regeneration and promote the formation of new, healthy skin cells. Due to their natural ability to accelerate wound healing, PNs are commonly used in the medical field for treating various skin conditions, including burns, ulcers, and post-surgical scars. When used in aesthetic treatments, PNs can improve the appearance of acne scarring, speed up the healing process after invasive procedures, minimize downtime and improve overall results.

  3. Hydration and Moisture Retention: PNs have hygroscopic properties, meaning they can attract and retain moisture. This leads to improved hydration levels within the skin, resulting in a plumper, smoother, and more supple appearance. Hydrated skin also helps improve the skin barrier function and reduce transepidermal water loss. By injecting PNs into the skin we address issues like dryness, roughness, and uneven skin tone.

  4. Antioxidant and Free Radical Scavenging: PNs exhibit antioxidant activity, which helps neutralize free radicals and protect the skin from oxidative stress. Free radicals are unstable molecules that can damage skin cells and contribute to premature aging. By scavenging these free radicals, PNs help reduce oxidative damage and inflammation, supporting a healthier, more youthful complexion.

  5. Anti-Inflammatory Effects: PNs possess anti-inflammatory properties, helping to reduce redness, swelling, and irritation. By inhibiting inflammatory responses in the skin, PNs can calm and soothe various skin conditions, making them suitable for individuals with sensitive or inflamed skin.

  6. Angiogenesis and Improved Blood Circulation: PNs have been found to stimulate angiogenesis, the formation of new blood vessels. This is crucial for improving blood circulation to the skin, ensuring an adequate supply of oxygen and nutrients. Improved blood flow helps nourish the skin, enhance its vitality, and promote a more youthful and radiant complexion.

The Polynucleotide Treatment Process:

Polynucleotide treatments typically involve a series of injections into the targeted area of the skin. Before the procedure, a numbing cream may be applied to ensure comfort during the treatment. The PNs are delivered using fine needles or micro-cannulas, depending on the specific treatment area and desired results. The treatment duration can vary but is generally quick, allowing individuals to resume their daily activities with minimal downtime.

Polynucleotide treatments should be performed by a trained and experienced medical professional who can evaluate your skin condition and customize the treatment plan to suit your needs.


Polynucleotides have emerged as a revolutionary non-surgical aesthetic treatment, offering a multitude of benefits for skin rejuvenation and revitalization. From stimulating collagen production and improving skin texture to enhancing wound healing and reducing inflammation, PNs have become a sought-after solution for individuals looking to achieve a more youthful and radiant complexion. If you're considering polynucleotide treatments, consult with a qualified aesthetic practitioner to understand if it is the right option for you and to ensure safe and effective results. Embrace the power of polynucleotides and unlock the potential of your skin's natural rejuvenation capabilities.

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